Our Papers

Diagnosis and Management of Myocarditis in Children: A Scientific Statement From the American Heart Association

Yuk M. Law, MD, FAHA, Chair; Ashwin K. Lal, MD, Vice Chair; Sharon Chen, MD, MPH; Daniela Čiháková, MD, PhD;
Leslie T. Cooper Jr, MD, FAHA; Shriprasad Deshpande, MBBS, MS; Justin Godown, MD; Lars Grosse-Wortmann, MD;
Joshua D. Robinson, MD; Jeffrey A. Towbin, MD, FAHA; on behalf of the American Heart Association Pediatric Heart Failure
and Transplantation Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young
and Stroke Council


Circulation. 2021 Jul 7:CIR0000000000001001. doi: 10.1161/CIR.0000000000001001. Online ahead of print.PMID: 34229446

Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis

Hee Sun Choi, Taejoon Won, Xuezhou Hou, Guobao Chen, William Bracamonte-Baran, Monica V. Talor, Ivana Jurcova , Ondrej Szarszoi, Lenka Curnova,  Ilja Strız, Jody E. Hooper, Vojtech Melenovsky, and Daniela Cihakova´
Cell ReportsVol. 30Issue 9p2989–3003.e6
Published in issue: March 03, 2020

ILC2s and Eosinophils Are Found near the Pericardium of the Right Ventricle of Rag2−/− Mice Treated with IL-33


The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis.

Hou X, Chen G, Bracamonte-Baran W, Choi HS, Diny NL, Sung J, Hughes D, Won T, Wood MK, Talor MV, Hackam DJ, Klingel K, Davogustto G, Taegtmeyer H, Coppens I, Barin JG, Čiháková D.

Cell Rep. 2019 Jul 2;28(1):172-189.e7. doi: 10.1016/j.celrep.2019.06.007.

PMID: 31269438

Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population.

Bracamonte-Baran W, Chen G, Hou X, Talor MV, Choi HS, Davogustto G, Taegtmeyer H, Sung J, Hackam DJ, Nauen D, Čiháková D.

Front Immunol. 2019 Mar 29;10:634. doi: 10.3389/fimmu.2019.00634. eCollection 2019.

PMID: 30984196

Free PMC Article

Gut permeability and mimicry of the Glutamate Ionotropic Receptor NMDA type Subunit Associated with protein 1 (GRINA) as potential mechanisms related to a subgroup of people with schizophrenia with elevated antigliadin antibodies (AGA IgG).

Čiháková D, Eaton WW, Talor MV, Harkus UH, Demyanovich H, Rodriguez K, Feldman S, Kelly DL.

Schizophr Res2019 Jan 23. pii: S0920-9964(19)30007-6. doi: 10.1016/j.schres.2019.01.007. [Epub ahead of print]

PMID: 30685393

Sca-1+ cardiac fibroblasts promote development of heart failure.

Chen G, Bracamonte-Baran W, Diny NL, Hou X, Talor MV, Fu K, Liu Y, Davogustto G, Vasquez H, Taegtmeyer H, Frazier OH, Waisman A, Conway SJ, Wan F, Čiháková D.

Eur J Immunol2018 Jun 28. doi: 10.1002/eji.201847583. [Epub ahead of print]


Interleukin-10 stiffens the heart

Daniela Čiháková


Čiháková D, Eaton WW, Talor MV, Harkus UH, Demyanovich HK, Rodriguez K, Feldman S, Kelly DL.

Schizophr Res2018 May;195:585-586. doi: 10.1016/j.schres.2017.08.051. Epub 2017 Sep 6. No abstract available.

PMID: 28886891

Cardiac Autoimmunity: Myocarditis.

Bracamonte-Baran W, Čiháková D.

Adv Exp Med Biol2017;1003:187-221. doi: 10.1007/978-3-319-57613-8_10. Review.


Regulation of autoimmune myocarditis by host responses to the microbiome.

Barin JG, Talor MV, Diny NL, Ong S, Schaub JA, Gebremariam E, Bedja D, Chen G, Choi HS, Hou X, Wu L, Cardamone AB, Peterson DA, Rose NR, Čiháková D.

Exp Mol Pathol. 2017 Aug 16. pii: S0014-4800(17)30415-X. doi: 10.1016/j.yexmp.2017.08.003. [Epub ahead of print]

 Eosinophils in autoimmune diseases
Diny NL, Rose NR, Čiháková D.

Front Immunol. 2017 Apr 27;8:484. doi: 10.3389/fimmu.2017.00484. eCollection 2017. Review.

Jillian A. Fontes,Jobert G. Barin,Monica V. Talor,Natalie Stickel,Julie Schaub,Noel R. Rose,Daniela Čiháková

Immunity, Inflammation and Disease 13 March 2017

Eosinophil-derived IL-4 drives progression of myocarditis to inflammatory dilated cardiomyopathy.

Diny NL1, Baldeviano GC2, Talor MV2, Barin JG2, Ong S1, Bedja D3, Hays AG3, Gilotra NA3, Coppens I1, Rose NR1,2, Čiháková D4,2.

J Exp Med. 2017 Mar 16. pii: jem.20161702. doi: 10.1084/jem.20161702. [Epub ahead of print]

PMID: 28302646

Natural killer cells in inflammatory heart

SuFey Onga, 1,Noel R Rosea, b, 2,Daniela Cihakovaa, b

Clinical Immunology 2016 Nov 2016. http://dx.doi.org/10.1016/j.clim.2016.11.010

Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart.

Diny NL, Hou X, Barin JG, Chen G, Talor MV, Schaub J, Russell SD, Klingel K, Rose NR, Čiháková D.

Eur J Immunol. 2016 Sep 12. doi: 10.1002/eji.201646557. [Epub ahead of print] PMID:27621211

Collaborative Interferon-γ and Interleukin-17 Signaling Protects the Oral Mucosa from Staphylococcus aureus.

Barin JG1, Talor MV1, Schaub JA1, Diny NL2, Hou X2, Hoyer M1, Archer NK3, Gebremariam ES1, Davis MF4, Miller LS3, Rose NR5, Čiháková D6.

Am J Pathol. 2016 Jul 25. pii: S0002-9440(16)30220-6. doi: 10.1016/j.ajpath.2016.07.001. [Epub ahead of print]


Pathogenic IL-23 signaling is required to initiate GM-CSF-driven autoimmune myocarditis in mice.

Wu L, Diny NL, Ong S, Barin JG, Hou X, Rose NR, Talor MV, Čiháková D*. Eur J Immunol. 2016 Mar;46(3):582-92. doi: 10.1002/eji.201545924. Epub 2016 Jan 12.

Featured in publishing journal’s “In this issue”: IL-23 starts the avalanche and ensures destruction

Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration.

Ong S, Ligons DL, Barin JG, Wu L, Talor MV, Diny N, Fontes JA, Gebremariam E, Kass DA, Rose NR, Čiháková D*. Am J Pathol. 2015 Mar;185(3):847-61. doi: 10.1016/j.ajpath.2014.11.023. Epub 2015 Jan 23.

Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy.

Wu L, Ong S, Talor MV, Barin JG, Baldeviano GC, Kass DA, Bedja D, Zhang H, Sheikh A, Margolick JB, Iwakura Y, Rose NR, Ciháková D* J Exp Med. 2014 Jun 30;211(7):1449-64. doi: 10.1084/jem.20132126. Epub 2014 Jun 16.

Faculty of 1000 Review

Picture featured in sidebar of Table of Contents: J Exp Med June 2014 Table of Contents

The varying faces of IL-6: From cardiac protection to cardiac failure.

Fontes JA, Rose NR, Čiháková D*Cytokine. 2015 Jul;74(1):62-8. doi: 10.1016/j.cyto.2014.12.024. Epub 2015 Jan 31.

Fatal eosinophilic myocarditis develops in the absence of IFN-γ and IL-17A.

Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Fairweather D, Bedja D, Stickel NR, Fontes JA, Cardamone AB, Zheng D, Gabrielson KL, Rose NR, Ciháková D*. J Immunol. 2013 Oct 15;191(8):4038-47. doi: 10.4049/jimmunol.1301282. Epub 2013 Sep 18.

Control of inflammatory heart disease by CD4+ T cells.

Barin JG, Čiháková D*. Ann N Y Acad Sci. 2013 May;1285:80-96. doi: 10.1111/nyas.12134.

Susceptibility to autoimmune myocarditis is associated with intrinsic differences in CD4(+) T cells.

Chen P, Baldeviano GC, Ligons DL, Talor MV, Barin JG, Rose NR, Ciháková D*. Clin Exp Immunol. 2012 Aug;169(2):79-88. doi: 10.1111/j.1365-2249.2012.04598.x.

Macrophage diversity in cardiac inflammation: a review.

Barin JG, Rose NR, Ciháková D*. Immunobiology. 2012 May;217(5):468-75. doi: 10.1016/j.imbio.2011.06.009. Epub 2011 Jun 30.

Macrophages participate in IL-17-mediated inflammation.

Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Quader F, Chen P, Zheng D, Caturegli P, Rose NR, Ciháková D*. Eur J Immunol. 2012 Mar;42(3):726-36. doi: 10.1002/eji.201141737. Epub 2012 Jan 23.

Mechanisms of IFNγ regulation of autoimmune myocarditis.

Barin JG, Talor MV, Baldeviano GC, Kimura M, Rose NR, Ciháková D*. Exp Mol Pathol. 2010 Oct;89(2):83-91. doi: 10.1016/j.yexmp.2010.06.005. Epub 2010 Jun 25.

Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy.

Baldeviano GC, Barin JG, Talor MV, Srinivasan S, Bedja D, Zheng D, Gabrielson K, Iwakura Y, Rose NR, Čiháková D*. Circ Res. 2010 May 28;106(10):1646-55. doi: 10.1161/CIRCRESAHA.109.213157. Epub 2010 Apr 8.

Featured in publishing journal’s “In this issue”: IL-17A Is Essential for Dilated Cardiomyopathy

*Corresponding author

Collaborative Papers