The Lotan Laboratory is located in the Department of Pathology in the Johns Hopkins University School of Medicine. The basic science research in our lab is focused on studying how mTORC1 oncogenic signaling pathway regulate epithelial development and tumor progression, using novel transgenic mouse models combined with human tumor tissue samples. The translational research program in our lab is centered on the analytic, pre-analytic and clinical validation of a number of tissue-based biomarkers in prostate cancer which are useful for molecular classification of prostate tumors and which may serve as prognostic and/or predictive biomarkers.