The Laboratory for Precision Immunology

The Larman Laboratory is part of the Immunology Division in the Pathology Department at the Johns Hopkins University School of Medicine, in Baltimore, Maryland, USA. The lab is situated within theĀ Institute for Cell Engineering‘s Immunobiology Program. Our efforts are devoted to developing and deploying cutting edge technologies that can be used to define human immune responses at cohort scale. Much of our work leverages sample handling automation and ‘next generation’ DNA sequencing, which enables massively parallel molecular measurements. Examples of our technologies include:

  • bacteriophage display of synthetic peptidome libraries for comprehensive, quantitative profiling of antibodies;
  • display of ORFeome libraries for antigen discovery, protein-protein interaction studies, and drug target identification;
  • highly efficient immune receptor repertoire analyses; and
  • ultrasensitive, multiplex RNA quantification techniques to monitor gene expression and detect microbes.

The Larman Laboratory uses these and other approaches to precisely characterize human immune responses.