The Cervical Cancer Research Laboratory has produced over 200 publications. The following list of publications is a sample of our most recent publications. It represents a compilation of journal and review articles that highlight advances in our current research and knowledge of vaccines against HPV-associated cervical cancer.
Tseng SH, Liu L, Peng S, Kim J, Ferrall L, Hung CF, Wu T-. Control of Spontaneous HPV16 E6/E7 Expressing Oral Cancer in HLA-A2 (AAD) Transgenic Mice with Therapeutic HPV DNA Vaccine. J Biomed Sci. 2021 Sep 13;28(1):63. doi: 10.1186/s12929-021-00759-x. PMID: 34517865; PMCID: PMC8436567.
Henkle TR, Lam B, Kung YJ, Lin J, Tseng SH, Ferrall L, Xing D, Hung CF, Wu TC. Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7-Expressing Carcinoma in the Cervicovaginal Tract. Cancer Res. 2021 Sep 1;81(17):4560-4569. doi: 10.1158/0008-5472.CAN-21-0399. Epub 2021 Jul 2. PMID: 34215618; PMCID: PMC8416934.
Ferrall L, Lin KY, Roden RBS, Hung CF, Wu TC. Cervical Cancer Immunotherapy: Facts and Hopes. Clin Cancer Res. 2021 Sep 15;27(18):4953-4973. doi: 10.1158/1078-0432.CCR-20-2833. Epub 2021 Apr 22. PMID: 33888488; PMCID: PMC8448896.
Peng S, Ferrall L, Gaillard S, Wang C, Chi WY, Huang CH, Roden RBS, Wu TC, Chang YN, Hung CF. Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody. mBio. 2021 Jan 19;12(1):e03224-20. doi: 10.1128/mBio.03224-20. PMID: 33468698; PMCID: PMC7845631.
Farmer E, Cheng MA, Hung CF, Wu TC. Vaccination Strategies for the Control and Treatment of HPV Infection and HPV-Associated Cancer. Recent Results Cancer Res. 2021;217:157-195. doi: 10.1007/978-3-030-57362-1_8. PMID: 33200366; PMCID: PMC8564785.
Kang TH, Yang A, Tsai Y, Ferrall L, Hung CF. Targeted tumor coating with antigenic, CTL-recognizable peptides via Annexin A5 chimeric constructs following chemotherapy redirects adaptive CD8+ T cell immunity for tumor clearance. Cell Mol Immunol. 2021 Jun;18(6):1578-1580. doi: 10.1038/s41423-020-00563-x. Epub 2020 Nov 2. PMID: 33139904; PMCID: PMC8166831.
Peng S, Tan M, Li YD, Cheng MA, Farmer E, Ferrall L, Gaillard S, Roden RBS, Hung CF, Wu TC. PD-1 blockade synergizes with intratumoral vaccination of a therapeutic HPV protein vaccine and elicits regression of tumor in a preclinical model. Cancer Immunol Immunother. 2021 Apr;70(4):1049-1062. doi: 10.1007/s00262-020-02754-x. Epub 2020 Oct 27. PMID: 33108473; PMCID: PMC7979473.
Feng PH, Lam B, Tseng SH, Kung YJ, Farmer E, Cheng MA, Hung CF. NKG2D-Fc fusion protein promotes antitumor immunity through the depletion of immunosuppressive cells. Cancer Immunol Immunother. 2020 Oct;69(10):2147-2155. doi: 10.1007/s00262-020-02615-7. Epub 2020 May 28. PMID: 32468232; PMCID: PMC7529872.
Kang TH, Park JH, Yang A, Park HJ, Lee SE, Kim YS, Jang GY, Farmer E, Lam B, Park YM, Hung CF. Annexin A5 as an immune checkpoint inhibitor and tumor-homing molecule for cancer treatment. Nat Commun. 2020 Feb 28;11(1):1137. doi: 10.1038/s41467-020-14821-z. PMID: 32111835; PMCID: PMC7048819.
Lee SY, Oh JY, Kang TH, Shin HS, Cheng MA, Farmer E, Wu TC, Hung CF. Endoplasmic reticulum stress enhances the antigen-specific T cell immune responses and therapeutic antitumor effects generated by therapeutic HPV vaccines. J Biomed Sci. 2019 May 27;26(1):41. doi: 10.1186/s12929-019-0536-7. PMID: 31133013; PMCID: PMC6535840.
Qiu J, Peng S, Ma Y, Yang A, Farmer E, Cheng MA, Roden RBS, Wu TC, Chang YN, Hung CF. Epithelial boost enhances antigen expression by vaccinia virus for the generation of potent CD8+ T cell-mediated antitumor immunity following DNA priming vaccination. Virology. 2018 Dec;525:205-215. doi: 10.1016/j.virol.2018.09.019. Epub 2018 Oct 5. PMID: 30296681; PMCID: PMC6415901.
Qiu J, Peng S, Yang A, Ma Y, Han L, Cheng MA, Farmer E, Hung CF, Wu TC. Intramuscular vaccination targeting mucosal tumor draining lymph node enhances integrins-mediated CD8+ T cell infiltration to control mucosal tumor growth. Oncoimmunology. 2018 May 24;7(8):e1463946. doi: 10.1080/2162402X.2018.1463946. PMID: 30221059; PMCID: PMC6136882.
Mao CP, Peng S, Yang A, He L, Tsai YC, Hung CF, Wu TC. Programmed self-assembly of peptide-major histocompatibility complex for antigen-specific immune modulation. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4032-E4040. doi: 10.1073/pnas.1718434115. Epub 2018 Apr 9. PMID: 29632186; PMCID: PMC5924900.
Xing D, Zheng G, Schoolmeester JK, Li Z, Pallavajjala A, Haley L, Conner MG, Vang R, Hung CF, Wu TC, Ronnett BM. Next-generation Sequencing Reveals Recurrent Somatic Mutations in Small Cell Neuroendocrine Carcinoma of the Uterine Cervix. Am J Surg Pathol. 2018 Jun;42(6):750-760. doi: 10.1097/PAS.0000000000001042. PMID: 29505425; PMCID: PMC5943084.
Lin YH, Yang MC, Tseng SH, Jiang R, Yang A, Farmer E, Peng S, Henkle T, Chang YN, Hung CF, Wu TC. Integration of Oncogenes via Sleeping Beauty as a Mouse Model of HPV16+ Oral Tumors and Immunologic Control. Cancer Immunol Res. 2018 Mar;6(3):305-319. doi: 10.1158/2326-6066.CIR-16-0358. Epub 2018 Jan 23. PMID: 29362220; PMCID: PMC6056342.
Cheng MA, Farmer E, Huang C, Lin J, Hung CF, Wu TC. Therapeutic DNA Vaccines for Human Papillomavirus and Associated Diseases. Hum Gene Ther. 2018 Sep;29(9):971-996. doi: 10.1089/hum.2017.197. Epub 2018 Mar 16. PMID: 29316817; PMCID: PMC6152857.
Yang A, Peng S, Farmer E, Zeng Q, Cheng MA, Pang X, Wu TC, Hung CF. Enhancing antitumor immunogenicity of HPV16-E7 DNA vaccine by fusing DNA encoding E7-antigenic peptide to DNA encoding capsid protein L1 of Bovine papillomavirus. Cell Biosci. 2017 Aug 23;7:46. doi: 10.1186/s13578-017-0171-5. PMID: 28852471; PMCID: PMC5569540.
Song KH, Choi CH, Lee HJ, Oh SJ, Woo SR, Hong SO, Noh KH, Cho H, Chung EJ, Kim JH, Chung JY, Hewitt SM, Baek S, Lee KM, Yee C, Son M, Mao CP, Wu TC, Kim TW. HDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells. Cancer Res. 2017 Sep 15;77(18):5039-5053. doi: 10.1158/0008-5472.CAN-17-0072. Epub 2017 Jul 17. PMID: 28716899; PMCID: PMC8171587.
Yang A, Farmer E, Lin J, Wu TC, Hung CF. The current state of therapeutic and T cell-based vaccines against human papillomaviruses. Virus Res. 2017 Mar 2;231:148-165. doi: 10.1016/j.virusres.2016.12.002. Epub 2016 Dec 6. PMID: 27932207; PMCID: PMC5325765.
Sun YY, Peng S, Han L, Qiu J, Song L, Tsai Y, Yang B, Roden RB, Trimble CL, Hung CF, Wu TC. Local HPV Recombinant Vaccinia Boost Following Priming with an HPV DNA Vaccine Enhances Local HPV-Specific CD8+ T-cell-Mediated Tumor Control in the Genital Tract. Clin Cancer Res. 2016 Feb 1;22(3):657-69. doi: 10.1158/1078-0432.CCR-15-0234. Epub 2015 Sep 29. PMID: 26420854; PMCID: PMC4738102.
Kang TH, Mao CP, La V, Chen A, Hung CF, Wu TC. Innovative DNA vaccine to break immune tolerance against tumor self-antigen. Hum Gene Ther. 2013 Feb;24(2):181-8. doi: 10.1089/hum.2012.141. Epub 2013 Jan 30. PMID: 23268564; PMCID: PMC3581028.
Kang TH, Ma B, Wang C, Wu TC, Hung CF. Targeted coating with antigenic peptide renders tumor cells susceptible to CD8(+) T cell-mediated killing. Mol Ther. 2013 Mar;21(3):542-53. doi: 10.1038/mt.2012.233. Epub 2012 Nov 27. PMID: 23183537; PMCID: PMC3589158.
Noh KH, Kim BW, Song KH, Cho H, Lee YH, Kim JH, Chung JY, Kim JH, Hewitt SM, Seong SY, Mao CP, Wu TC, Kim TW. Nanog signaling in cancer promotes stem-like phenotype and immune evasion. J Clin Invest. 2012 Nov;122(11):4077-93. doi: 10.1172/JCI64057. Epub 2012 Oct 24. PMID: 23093782; PMCID: PMC3484451.
Trimble CL, Peng S, Kos F, Gravitt P, Viscidi R, Sugar E, Pardoll D, Wu TC. A phase I trial of a human papillomavirus DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3. Clin Cancer Res. 2009 Jan 1;15(1):361-7. doi: 10.1158/1078-0432.CCR-08-1725. PMID: 19118066; PMCID: PMC2865676. Cheng WF, Hung CF, Chai CY, Hsu KF, He L, Ling M, Wu TC. Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen. J Clin Invest. 2001 Sep;108(5):669-78. doi: 10.1172/JCI12346. PMID: 11544272; PMCID: PMC209378.