Core B

The Biostatistics and Bioinformatics Core (Core B) will provide centralized statistical services and molecular assay validation support for the research program of the SPORE for cervical cancer. Core B will sustain the Cervical Cancer SPORE by providing innovative statistical and bioinformatical approaches as well as seamless consultation and advanced database management in compliance with NIH and FDA regulations. The primary objective of Core B is to provide aid and direction in experimental design, assay methodology, quantitative data analysis and interpretation through consultation and collaboration. The existence of a core group of biostatistics and bioinformatics specialists and molecular assay expert ensures a common approach to design, data generation, and analysis across projects. The Core provides each project with the resources needed to address its aims in an efficient manner by sharing expertise across projects. It contributes to dissemination of state-of-the art quantitative analysis techniques to all SPORE investigators and oversees the quality of the underlying data. By centralizing this resource, the Core members are positioned to initiate and promote interdisciplinary interactions among projects. In addition to the pre-specified input into project design and analysis, biostatisticians have equally important informal interactions that are critical to meaningful involvement in the research process. The Core personnel participate in regular project and program meetings, provide input on quantitative matters arising in the projects, and are available for informal consultation at all times. The Core will serve as the focal point from which SPORE investigators and Career Development Program Awardees and Developmental Research Program Awardees can draw statistical and bioinformatical expertise for the design, data management and analysis of its research projects. In particular, the Specific Aims are to:  

1. Provide biostatistical and bioinformatical consultation and support by assisting in experimental design and data collection, visualization, analysis, quantitative modeling, interpretation, publication and sharing for all SPORE projects.  
2. Provide biostatistical and bioinformatical support for the Tissue/Pathology/Immunology Core C, the Developmental Research Program (DRP) awardees, and the Career Enhancement Program (CEP) awardees.  
3. Advice and support the development of centralized facilities and protocols for data storage, management, and dissemination.  
4. Support HPV and other molecular testing development and validation that complies with CLIA regulations for the clinical testing proposed in the SPORE projects and provide biomarker assay research methodology and experiment design support for the Tissue/Pathology/Immunology Core C, the DRP awardees, and the CEP awardees. 

Investigators