Team

Principal Investigator

H. Benjamin Larman, Ph.D.

Larman_6735_fullFile_sq

Originally from Portland, Maine, Ben earned his B.S. in Engineering Physics and Bioengineering from UC Berkeley in California. He went on to obtain his Ph.D. from Harvard-MIT’s Division of Health Sciences & Technology in the laboratory of Steve Elledge, developing new molecular assays such as “Phage ImmunoPrecipitation sequencing” (PhIP-seq), and “ParalleL Analysis of Translated ORFs” (PLATO). He then postdoc’ed with Pete Schultz at The Scripps Research Institute in La Jolla, CA, where he worked on high throughput screening methods, including “RNA Annealing, Selection and Ligation sequencing” (RASL-seq). Ben started his own laboratory in the Pathology Department at Johns Hopkins in 2014, within the Division of Immunology. Here, our team develops and deploys massively multiplexed technologies to better understand human immune responses in sickness and in health.

Postdoctoral Fellows

Joel Credle, Ph.D.

Joel earned his bachelor’s degree from Radford University and his Ph.D. from Georgetown University.  Joel solved the first crystal structure of IRE1, a sensor of unfolded proteins within the ER while in the lab of Peter Walter at UC San Francisco.  Joel’s Ph.D. involved elucidating the role of the unfolded protein response in the progression of Parkinson’s disease. In the Larman lab, Joel has developed a new technique for analyzing RNA in clinical FFPE tissue specimens, which is called Ligation in situ Hybridization (‘LISH’).s

Tiezheng Yuan, Ph.D.

Yuan_TiezhengTiezheng earned his undergraduate B.S. in Biotechnology at the Ocean University of China. He then went on to obtain a Ph.D. in Biochemistry and Molecular Biology from the Chinese Academy of Agricultural Sciences. Tiezheng’s work has led to the discovery of plasma-derived exosomal non-coding RNA biomarkers, as well as gene expression signatures characteristic of aggressive prostate cancer. He has also developed powerful software suites (eRNA and 3C-analyzer) to facilitate analysis of NGS datasets. In the Larman Lab, Tiezheng is developing informatics pipelines and algorithms to interpret our growing database of PhIP-seq data sets.

Gabriel Roman, Ph.D.

IMG_7466Gabriel began studying chemistry at the University of Puerto Rico and finished his B.S. at Baylor University. Working with professor Neil Marsh, he earned his Ph.D. from the University of Michigan studying how a particular class of enzymes is able generate highly-reactive radical intermediates and direct them toward productive catalysis (Biochemistry 53, 169-177). Currently a postdoctoral fellow in the Larman lab, Gabriel is developing post-translational modification-based applications for Phage ImmunoPrecipitation sequencing (PhIP-seq).

Raja Venkataraman, Ph.D.

Raja grew up in the city of Chennai, India. He earned his Bachelor’s degree (Biosciences) and Master’s degree (Biotechnology) in India before he moved to the United States. Having always been interested in immune responses against viral pathogens, he investigated anti-viral signaling mechanisms focusing on the role of the Rig-I-like receptor (RLRs) LGP2 and how it contributes to interferon signaling at the University of Miami’s Miller School of Medicine. Raja earned his Ph.D studying host responses against the SARS coronavirus at the University of Maryland School of Medicine. In the Larman lab, he is investigating the heritability of anti-viral humoral responses using VirScan and developing novel applications for PhIP-Seq.

Graduate Students

Janelle Montagne

Janelle earned her B.S. in biochemistry from Lafayette College and her M.S. in biotechnology from the Johns Hopkins University. She previously worked as a Research Specialist studying mechanisms of systemic autoimmune diseases in the Division of Rheumatology here at Hopkins. As a graduate student in the Pathobiology Program, Janelle is developing new techniques for understanding T cell specificities and phenotypes.

Daniel Monaco

Daniel earned his B.S. in Biomedical Engineering from the University of Virginia in 2016. His undergraduate research involved the utilization of novel biomarkers for the detection of pancreatic cancer. As a graduate student in the Pathobiology Program, Daniel is developing new techniques for the PhIP-Seq platform and is working on improved algorithms​ for PhIP-Seq data analysis.

Meng-Hsuan (Erin) Hsiao

Erin earned her B.S. and M.S. in Chemical Engineering from National Tsing-Hua University in Taiwan. Her previous studies involved polymer engineering and drug delivery, with a focus on fabrication of microneedles and loading processes. As a graduate student in the Chemical and Biomolecular Engineering Program, Erin is developing new methods for screening peptidome libraries for therapeutic applications.

Scientific Staff

Brandon Sie

Brandon Sie

Brandon earned his B.S. in Bioengineering from the University of California, Berkeley in 2015. His undergrad research included an investigation of the correlation between regional clusters of Parkinson’s Disease and agricultural use of the pesticide permethrin, which he presented at the Society of Toxicology annual meeting in 2016. After college, Brandon accepted a research fellowship with the Food and Drug Administration through which he contributed to genetic toxicology risk assessment for newly regulated food additives and food contact substances. Brandon currently performs PhIP-Seq analysis as a research technologist in the Larman lab.

Divya Mohan

16402_980039898682432_3705954716391697350_n (1)Divya earned her undergraduate degree from Patna University, India, and her masters degree from the University of Delhi, India. Before joining the Larman lab, Divya Worked as a Research Technician for two years in the Department of Medicine at Johns Hopkins. Currently, she performs high throughput human antibody analyses using the PhIP-seq technology platform.

Interns

Xuwen “Alice” Zheng

Alice is an undergraduate student at Johns Hopkins University majoring in Mathematics and minoring in Computational Medicine. She is working with graduate student Janelle Montagne on the study of T cell specificities.

Jonathan Gunn

Jonathan is an undergraduate at Johns Hopkins majoring in Chemical and Biomolecular Engineering and Mathematics. Jonathan is working with postdoctoral fellow Dr. Joel Credle on a novel method to display libraries of full length proteins. Jonathan is an aspiring physician-scientist.

Julia Angkeow

Julia is an incoming first year student at Columbia College of Columbia University who is interested in biomedical research. She is currently working with intern Sanjay Kottapalli on characterization of humoral immune responses to the enteric virome.

Alumni

Sanjay Kottapalli

Azaan Wilbon

Daniel Wansley, Ph.D.

Chris Itoh

Muhammad Noon