The structures of the medial temporal lobe are involved in both spatial navigation and memory. Despite great progress, the mechanisms remain mysterious. Our laboratory focuses on the circuitry of the human medial temporal lobe and changes over the lifespan. We work along the following three avenues:
— Improved characterization of the cellular structure of the circuit in three dimensions.
— Investigation of changes in the circuit and its capillary supply in aging and Alzheimer’s disease.
— Development of a system for creation of in vitro two dimensional model circuits to provide more direct understanding of circuit properties.
If these approaches to understanding the mechanisms of human memory interest you, please get in touch.
Developing human hippocampus and subiculum, with adjacent germinal matrix