Led by colleagues at Dana-Farber and the Broad Institute, and in collaboration with members of our group, this study in Nature Medicine highlights a robust molecular stratification (based on enhancer signatures) of non-functional pancreatic neuroendocrine tumors that may ultimately help to inform postoperative clinical decisions.
In the latest issue of Science Translational Medicine, the Castro/Lowenstein laboratory at the University of Michigan, in collaboration with members of our group, demonstrates in mouse models that pharmacological inhibition of the DNA damage response sensitizes IDH1-mutant gliomas to radiation, thereby highlighting a new therapeutic strategy.
Our latest work demonstrating a telomere DNA expansion on human retinal rod photoreceptors is associated with aging and disease was highlighted on the cover of Brain Pathology!
Today is bittersweet as we say goodbye to Dr. Jacqueline Brosnan-Cashman. We wish her all the best in her new position as the Scientific Editor at Clinical Cancer Research. Good luck, Jackie!
Check out the article, Personalized postdoctoral fellowship care, by Dr. Mindy Graham and her colleagues from The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center Postdoctoral Organization (C3PO) in Nature Biotechnology. Here, the authors explain how "adapting the clinical residency training model can help postdoctoral research fellows navigate and personalize their training experience for their unique career goals".
Through a collaborative effort, members of our research group have helped to identify SMARCAL1 inactivating mutations (a novel genetic mechanism of ALT) and chromosomal rearrangements upstream of TERT (a novel mechanism of telomerase activation) in glioblastomas. Check out the study in the latest issue of Nature Communications.
Check out the recent review article/editorial "Cancer telomeres and white crows" from Dr. Meeker that pays tribute to the late Dr. Donald S. Coffey, former Director of Urologic Research at the Brady Urological Research Institute.
Congratulations to Drs. Jacqueline Brosnan-Cashman and Mindy Graham for winning basic science research awards at the 20th Annual Johns Hopkins Department of Pathology Young Investigators’ Day!
Dr. Jacqueline Brosnan-Cashman gives a talk titled "ATRX loss induces hallmarks associated with alternative lengthening of telomeres" at the 2018 Baltimore Area Repair Symposium.
Thanks to our undergraduate student researchers from Johns Hopkins (Jeannie, Kaylar, and Rebecca) for all their hard work and contributions to our ongoing studies. Good luck to all of them on their future studies!
Congratulations, Walter! He successfully defended his doctoral thesis titled "The PML protein is not essential for telomere maintenance by the alternative lengthening of telomeres pathway (ALT) and its deletion modifies ALT biomarkers".
After 3+ years in the lab, today we bid farewell to Anthony Rizzo as he pursues new opportunities and adventures. Good luck in CO, Anthony!
Check out the excellent review article by Drs. Mindy Graham and Alan Meeker on Telomeres and telomerase in prostate cancer development and therapy in Nature Reviews Urology.
Dr. Mindy Graham recently was the Chair of the Gordon Research Seminar on Nucleosides, Nucleotides and Oligonucleotides and the co-organizer of the Power Hour at the Gordon Research Conference.
Congratulations to Dr. Mindy Graham for receiving an Honorable Mention award for Basic Research in the Annual SKCCC at Johns Hopkins Fellow Research Day!
Dr. Jacqueline Brosnan-Cashman presents her latest research findings on the "Context-dependent effects of ATRX loss on telomere biology in glioma cells" at the Telomeres and Telomerase meeting at the Cold Spring Harbor Laboratory.
Congratulations to Dr. Jacqueline Brosnan-Cashman for being selected to receive a NCI T32 postdoctoral training fellowship in cancer biology supported through the Department of Biochemistry and Molecular Biology at the Johns Hopkins Bloomberg School of Public Health!
Congratulations to Dr. Mindy Graham for receiving a Ruth L. Kirschstein National Research Service Award for a postdoctoral fellowship from the NIH!
Thank you to The Sol Goldman Pancreatic Cancer Research Center for generously supporting our research! In collaboration with the Wood Laboratory, Dr. Heaphy recently received a pilot project grant to study telomere biology in patients with IPMN.
The Bond Street Labs were recently highlighted in PathWays - the annual newsletter from the Department of Pathology at Johns Hopkins.
The laboratory of Dr. Fausto Rodriguez, in collaboration with our group, has uncovered additional genetic links to brain cancer cell growth.
Dr. Heaphy received the 2016 North American Neuroendocrine Tumors Society (NANETS) Basic/Translational Science Investigator Award. The award is sponsored by the Neuroendocrine Tumor Research Foundation with the generous support of the Margie & Robert E. Peterson Foundation. We are excited to be part of the NET research community!
Congratulations to Dr. Mindy Graham for being named one of the Chief Research Fellows for The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center Postdoctoral Organization (C3PO).
Congratulations to our colleagues at the Bloomberg School of Public Health and the School of Medicine, including Dr. Meeker, for receiving a Johns Hopkins Discovery Award to facilitate an interdisciplinary faculty team focusing on Cancer in Older Adults.
Congratulations to Dr. Jacqueline Brosnan-Cashman for receiving a research grant from the Collaborative Pediatric Cancer Research Awards Program to study high grade gliomas. The grant is co-funded by The Truth 365 and the Rally Foundation for Childhood Cancer Research.
Congratulations to Reza Zarinshenas for his acceptance into medical school! Reza is joining the Class of 2020 at the University of Wisconsin-Madison School of Medicine and Public Health.
Congratulations to postdoctoral fellows, Drs. Mindy Graham and Jacqueline Brosnan-Cashman, for winning research awards at the annual Johns Hopkins Department of Pathology Young Investigators’ Day!
Dr. Heaphy presents on the molecular hallmarks of neuroendocrine tumor development during a plenary session at the 13th Annual European Neuroendocrine Tumor Society (ENETS) Conference in Barcelona, Spain.
The Castro/Lowenstein laboratory at the University of Michigan, in collaboration with our group, has developed a novel brain tumor model in mice that represents a new weapon in the fight against children's brain tumors.
Our recent study in collaboration with our colleagues at the Johns Hopkins Bloomberg School of Public Health was highlighted in DISCOVERY, a publication of the Patrick C. Walsh Prostate Cancer Research Fund and the James Buchanan Brady Urological Institute at Johns Hopkins.
Dr. Meeker, in collaboration with Dr. Philip Jordan at the Johns Hopkins Bloomberg School of Public Health, receives one of the inaugural 2015 Johns Hopkins Discovery Awards.
Our ongoing telomere research was recently highlighted in DISCOVERY, a publication of the Patrick C. Walsh Prostate Cancer Research Fund and the James Buchanan Brady Urological Institute at Johns Hopkins.
Dr. Heaphy receives a Prostate Cancer Foundation (PCF) Young Investigator award for his proposal to evaluate the telomere biomarker for individualized prostate cancer risk stratification and prognostication.
The MAGAZINE of the Johns Hopkins Bloomberg School of Public Health has written a story called Telomere Express that highlights our recent work published in Cancer Discovery.
Thank you to the Patrick C. Walsh Prostate Cancer Research Fund! Dr. Heaphy was named the 2014 Dr. and Mrs. Peter S. Bing Scholar as we continue to assess if abnormal telomere biology contributes to racial differences in prostate cancer.
The Pancreatic Cancer Sequencing Team in the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins, including Dr. Meeker, receives the Team Science Award from the American Association for Cancer Research (AACR)!
Our paper Altered telomeres in tumors with ATRX and DAXX mutations was recently highlighted in JAMA.
Dr. Heaphy receives an award for Excellence in Translational Research at the 13th Annual Johns Hopkins Department of Pathology Young Investigator’s Day.
Congratulations to Dr. Heaphy for receiving the prestigious Stowell-Orbison Award at the United States and Canadian Academy of Pathology (USCAP) Annual Meeting for his poster titled "Alternative lengthening of Telomeres in Human Carcinoma Subtypes".