Multi-Omics to Identify Novel Therapeutic Targets in Eye and Brain Tumors
Our laboratory utilizes multi-omics approaches to identify novel therapeutic targets in eye and brain tumors. Our studies identify signaling pathways cancer cells rely on for growth and survival and distinguishes cancer cells from normal human cells.
Pre-Clinical Drug Testing to Improve Therapies for Eye and Brain Tumors
We complete extensive pre-clinical drug testing to identify novel therapeutics to improve treatments for eye and brain tumors. These studies are focused on translating novel therapies into new clinical trials aimed at improving survival and reducing side effects of therapy. We complete rigorous pre-clinical studies including formal synergy studies, pharmacokinetics and pharmacodynamics evaluations, toxicity profiling, and survival studies in multiple orthotopic tumor models to ensure the successful translation into new and successful clinical trials. We also work to develop the correlative studies that help ensure that the clinical trial will improve our understanding of tumor biology and response to therapeutics so clinical trials continue to build on these developments.
Tumor Modeling to Improve our Understand of Eye and Brain Tumors
Our understanding of eye and brain tumors is only as good as the models we use to study them. We have assembled one of the largest collections of eye and brain tumor human-derived cell models and patient derived xenograft models. We have also developed new techniques to improve the number of successful models developed from surgical biopsies and autopsy specimesn. In addition we have developed zebra fish models to better image and test therapeutics in eye and brain tumors.