Publications

Selected

  1. Sun S, Sun Y, Ling SC, Ferraiuolo L, McAlonis-Downes M, Zou Y, Drenner K, Wang Y, Ditsworth D, Tokunaga S, Kopelevich A, Kaspar BK, Lagier-Tourenne C, and Cleveland DW. (2015) Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS. Proc Natl Acad Sci U S A. 112(50): E6993-7002.
  2. Jovicic A, Paul J III, Boeynaems S, Bogaert E, Mertens J, Chai N, Yamada SB, Sun S, Herdy J, Bieri G, Kramer NJ, Gage FH, Bosch LV, Robberecht W, and Gitler AD. (2015) Genetic screens identify potent modifiers of C9orf72 dipeptide repeat protein toxicity and implicate nucleocytoplasmic transport impairments in c9FTD/ALS. Nature Neuroscience 18(9): 1226-1229.
  3. Israelson A, Ditsworth D, Sun S, Song SW, Liang J, Hruska-Plochan M, McAlonis-Downes M, Abu-Hamad S, Zoltsman G, Shani T, Maldonado M, Bui A, Navarro M, Zhou H, Marsala M, Kaspar BK, Da Cruz S, Cleveland DW. (2015) Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1. Neuron 86(1): 218-32.
  4. Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland DW. (2015) ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nature Communications 6: 6171.
  5. Weyn-Vanhentenryck SM, Mele A, Yan Q,Sun S, Farny N, Zhang Z, Xue C, Herre M, Silver PA, Zhang MQ, Krainer AR, Darnell RB, Zhang C. (2014) HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Cell Reports 6: 1139-52.
  6. Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD, Bennett CF, Cleveland DW, Ravits J. (2013) Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci USA. 110: E4530-9.
  7. Sun S, Cleveland DW. (2012) TDP-43 toxicity and the usefulness of junk. Nature Genetics 44: 1289-91.
  8. SunS, Zhang Z, Fregoso O, Krainer  (2012) Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2. RNA 18: 274-83.
  9. Wu J, Akerman M,Sun S, McCombie WR, Krainer AR, Zhang MQ. (2011) SpliceTrap: a method to quantify alternative splicing under single cellular conditions. Bioinformatics 27: 3010-6.
  10. Wu H,Sun S, Tu K, Gao Y, Xie B, Krainer AR, Zhu J. (2010) A splicing-independent function of SF2/ASF in microRNA processing. Molecular Cell 38: 67-77.
  11. SunS, Zhang Z, Sinha R, Karni R, Krainer  (2010) SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control. Nature Structural & Molecular Biology 17: 306-12.