Publications

1. Fu X, Zhang Z, Hayes L, Wright N, Asbury J, Li S, Ye Y, Sun S. DDX3X overexpression decreases dipeptide repeat proteins in a mouse model of C9ORF72-ALS/FTD. Exp Neurol. 2024; 29:376:114768.
2. Dou X, Xiao Y, Shen C, Wang K, Wu T, Liu C, Li Y, Yu X, Liu J, Dai Q, Pajdzik K, Ye C, Ge R, Gao B, Yu J, Sun S, Chen M, Chen J, He C. RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation. Nat Cell Biol. 2023; 25(9): 1359-1368.
3. Latallo MJ, Wang S, Dong D, Nelson B, Livingston NM, Wu R, Zhao N, Stasevich TJ, Bassik MC, Sun S*, Wu B*. (2023) Single-molecule imaging reveals distinct elongation and frameshifting dynamics between frames of expanded RNA repeats in C9ORF72-ALS/FTD. Nature Communications 14: 5581.
4. Wang S and Sun S. (2023) Translation dysregulation in neurodegenerative diseases: a focus on ALS. Molecular Neurodegeneration 18:58.
5. Li Y, Dou X, Liu J, Xiao Y, Zhang Z, Wu R, Fu X, Ye Y, Hayes L, Ostrow L, *He C, *Sun S. (2023) Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration. Nature Neuroscience. doi: 10.1038/s41593-023-01374-9.
6. Dou X, Huang L, Xiao Y, Liu C, Li Y, Zhang X, Yu L, Zhao R, Yang L, Chen C, Yu X, Gao B, Qi M, Gao Y, Shen B, Sun S, He C, Liu J.(2023)  METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity. Protein Cell. doi: 10.1093/procel/pwad009.
7. Ling JP, Bygrave AM, Santiago CP, Carmen-Orozco RP, Trinh VT, Yu M, Li Y, Liu Y, Bowden KD, Duncan LH, Han J, Taneja K, Dongmo R, Babola TA, Parker P, Jiang L, Leavey PJ, Smith JJ, Vistein R, Gimmen MY, Dubner B, Helmenstine E, Teodorescu P, Karantanos T, Ghiaur G, Kanold PO, Bergles D, Langmead B, Sun S, Nielsen KJ, Peachey N, Singh MS, Dalton WB, Rajaii F, Huganir RL, Blackshaw S. (2022) Cell-specific regulation of gene expression using splicing-dependent frameshifting. Nature Communications 13(1):5773.
8. Wang S, Latallo MJ, Zhang Z, Huang B, Bobrovnikov DG, Dong D, Livingston NM, Tjoeng W, Hayes LR, Rothstein JD, Ostrow LW, Wu B*, Sun S*. (2021) Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD. Nature Communications 12:4908.
9. Zaepfel BL, Zhang Z, Maulding K, Coyne AN, Cheng W, Lloyd TE*, Sun S*, Rothstein JD*. (2021) UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction. Cell Reports 34(13): 108925.
10. Cheng W*, Wang S*, Zhang Z, Morgens DW, Hayes LR, Lee S, Portz B, Xie Y, Nguyen BV, Haney MS, Yan S, Dong D, Coyne AN, Yang J, Xian F, Cleveland DW, Qiu Z, Rothstein JD, Shorter J, Gao F-B, Bassik MC, Sun S. (2019) CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation. Neuron 104: 1-14.
11. Yang J, Chen J, Del Carmen Vitery M, Osei-Owusu J, Chu J, Yu H, Sun S, Qiu Z. (2019) PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel. Science. 26;364(6438):395-399.
12. Ling SC, Dastidar SG, Tokunaga S, Ho WY, Lim K, Ilieva H, Parone PA, Tyan SH, Tse TM, Chang JC, Platoshyn O, Bui NB, Bui A, Vetto A, Sun S, McAlonis-Downes M, Han JS, Swing D, Kapeli K, Yeo GW, Tessarollo L, Marsala M, Shaw CE, Tucker-Kellogg G, La Spada AR, Lagier-Tourenne C, Da Cruz S, Cleveland DW. (2019) Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis. Elife. 12;8.
13. Cheng W, Wang S, Mestre AA, Fu C, Makarem A, Xian F, Hayes LR, Lopez-Gonzalez R, Drenner K, Jiang J, Cleveland DW, Sun S. (2018) C9ORF72 GGGGCC Repeat-Associated Non-AUG Translation is upregulated by stress through eIF2α phosphorylation. Nature Communications 9:51.
14. Ditsworth D, Maldonado M, McAlonis-Downes M, Sun S, Seelman A, Drenner K, Arnold E, Ling SC, Pizzo D, Ravits J, Cleveland DW, Da Cruz S. (2017) Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis. Acta Neuropathol. 133(6):907-922.
15. Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. (2016) Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. 90(3):535-50.
16. Sun S, Sun Y, Ling SC, Ferraiuolo L, McAlonis-Downes M, Zou Y, Drenner K, Wang Y, Ditsworth D, Tokunaga S, Kopelevich A, Kaspar BK, Lagier-Tourenne C, and Cleveland DW. (2015) Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS. Proc Natl Acad Sci U S A. 112(50): E6993-7002.
17. Anczuków O, Akerman M, Cléry A, Wu J, Shen C, Shirole NH, Raimer A, Sun S, Jensen MA, Hua Y, Allain FH, Krainer AR. (2015) SRSF1-Regulated Alternative Splicing in Breast Cancer. Mol Cell. 60(1):105-17.
18. Jovicic A, Paul J III, Boeynaems S, Bogaert E, Mertens J, Chai N, Yamada SB, Sun S, Herdy J, Bieri G, Kramer NJ, Gage FH, Bosch LV, Robberecht W, and Gitler AD. (2015) Genetic screens identify potent modifiers of C9orf72 dipeptide repeat protein toxicity and implicate nucleocytoplasmic transport impairments in c9FTD/ALS. Nature Neuroscience 18(9): 1226-1229.
19. Israelson A, Ditsworth D, Sun S, Song SW, Liang J, Hruska-Plochan M, McAlonis-Downes M, Abu-Hamad S, Zoltsman G, Shani T, Maldonado M, Bui A, Navarro M, Zhou H, Marsala M, Kaspar BK, Da Cruz S, Cleveland DW. (2015) Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1. Neuron 86(1): 218-32.
20. Sun S, Ling SC, Qiu J, Albuquerque CP, Zhou Y, Tokunaga S, Li H, Qiu H, Bui A, Yeo GW, Huang EJ, Eggan K, Zhou H, Fu XD, Lagier-Tourenne C, Cleveland DW. (2015) ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nature Communications 6: 6171.
21. Weyn-Vanhentenryck SM, Mele A, Yan Q,Sun S, Farny N, Zhang Z, Xue C, Herre M, Silver PA, Zhang MQ, Krainer AR, Darnell RB, Zhang C. (2014) HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Cell Reports 6: 1139-52.
22. Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD, Bennett CF, Cleveland DW, Ravits J. (2013) Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci USA. 110: E4530-9.
23. Sun S, Cleveland DW. (2012) TDP-43 toxicity and the usefulness of junk. Nature Genetics 44: 1289-91.
24. SunS, Zhang Z, Fregoso O, Krainer  (2012) Mechanisms of activation and repression by the alternative splicing factors RBFOX1/2. RNA 18: 274-83.
25. Wu J, Akerman M,Sun S, McCombie WR, Krainer AR, Zhang MQ. (2011) SpliceTrap: a method to quantify alternative splicing under single cellular conditions. Bioinformatics 27: 3010-6.
26. Wu H,Sun S, Tu K, Gao Y, Xie B, Krainer AR, Zhu J. (2010) A splicing-independent function of SF2/ASF in microRNA processing. Molecular Cell 38: 67-77.
27. SunS, Zhang Z, Sinha R, Karni R, Krainer  (2010) SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control. Nature Structural & Molecular Biology 17: 306-12.
28. Zhang C, Zhang Z, Castle J, Sun S, Johnson J, Krainer AR, Zhang MQ (2008) Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes Dev. 22(18):2550-63.