The structures of the medial temporal lobe are involved in both spatial navigation and memory. Despite great progress, the mechanisms remain mysterious. Our laboratory focuses on the circuitry of the human medial temporal lobe and changes over the lifespan. We work along the following three avenues:
— Improved characterization of the structure of the circuit in three dimensions. Collaborative work with Jiangyang Zhang (NYU), Partha Mitra (CSHL), and Daniel Tward (UCLA).
— Investigation of changes in the circuit and its capillary supply in aging and Alzheimer’s disease. Collaborative work with Paul Worley (JHU).
— Development of a system for creation of in vitro two dimensional model circuits to provide more direct understanding of circuit properties.
If these approaches to understanding the mechanisms of human memory interest you, please get in touch.
Algorithmic identification of granule cells in dentate gyrus from two photon data, by filtering based on visual characteristics of chromatin (with Sophia Chang and Blackberrie Eddins)