Publications (Selected)

The rat spine after a lumbar spinal fusion procedure.
  1. Meyers CA, Xu J, Zhang L, Asatrian G, Ding C, Yan N, Broderick K, Sacks J, Goyal R, Zhang X, Ting K, Peault B, Soo C, James AW. Early immunomodulatory effects of implanted human perivascular stromal cells during bone formation. Tissue Engineering Part A. Jul 2017, Epub ahead of print.
  2. James AW, Shen J, Tsuei R, Nguyen A, Khadarian K, Meyers CA, Pan HC, Li W, Kwak JH, Asatrian G, Culiat CT, Lee M, Ting K, Zhang X, Soo C. NELL-1 induces Sca-1+ mesenchymal progenitor cell expansion in models of bone maintenance and repair. JCI Insight. Jun 2017, 2(12): Epub ahead of print.
  3. James AW, Zhang X, Crisan M, Hardy WR, Liang P, Meyers CA, Lobo S, Lagishetty V, Childers MK, Asatrian G, Ding C, Yen YH, Zou E, Ting K, Peault B, Soo C. Isolation and characterization of canine perivascular stem/stromal cells for bone tissue engineering. PLoS One. May 2017, 12(5): e0177308.
  4. Cocks M, Mohan A, Meyers CA, Ding C, Levi B, McCarthy E, James AW. Vascular patterning in human heterotopic ossification. Hum Pathol. Mar 2017; Epub ahead of print.
  5. Shen J, Chen X, Jia H, Meyers CA, Shrestha S, Asatrian G, Ding C, Tsuei R, Zhang X, Peault B, Ting K, Soo C, James AW. Effects of WNT3A and WNT16 on the osteogenic and adipogenic differentiation of perivascular stem cells. Tissue Eng Part A. May 2017, Epub ahead of print.
  6. James AW, Zhang X, Crisan M, Hardy WR, Liang P, Meyers CA, Lobo S, Lagishetty V, Childers MK, Asatrian G, Ding C, Yen YH, Zou E, Ting K, Peault B, Soo C. Isolation and characterization of canine perivascular stem/stromal cells for bone tissue engineering. PLoS One, May 2017, 12(5): e0177308.
  7. James AW, Shen J, Tsuei R, Nguyen A, Khadarian K, Meyers CA, Pan HC, Li W, Kwak JH, Asatrian G, Culiat CT, Lee M, Ting K, Zhang X, Soo C. NELL-1 induces Sca-1-positive mesenchymal progenitor cell expansion in models of bone maintenance and repair. JCI Insight, Apr 2017, Accepted for publication.
  8. Shrestha S, Meyers C, Shen J, Giacomelli P, Scott MA, Soo C, Dry SM, Ting K, James AW. Ang-1 and Ang-2 expression in angiomyolipoma and PEComa family tumors. J Orthop. Mar 2017; 14(1): 154-160.
  9. Lee S, Wang C, Pan HC, Shrestha S, Meyers C, Ding C, Shen J, Chen E, Lee M, Soo C, Ting K, James AW. Combining Smoothened Agonist (SAG) and Nel-like protein 1 (NELL-1) Enhances Bone Healing. Plast Reconst Surg. Jan 2017; Epub ahead of print.
  10. Lee S, Shen J, Pan HC, Shrestha S, Asatrian G, Nguyen A, Meyers C, Nguyen V, Lee M, Soo C, Ting K, James AW. Calvarial defect healing induced by small molecule smoothened agonist. Tissue Eng Part A. Dec 2016; 22(23-24): 1357-1366.
  11. Shen J, Meyers CA, Shrestha S, LaChaud G, Nguyen V, Asatrian G, Singh A, Federman N, Dry SM, Ting K, Soo C, James AW. Sclerostin expression in skeletal sarcomas. Hum Pathol. 2016 Dec; 58: 24-34.
  12. Shrestha S, Shen J, Giacomelli P, Scott MA, Soo C, Ting K, Peault B, Dry SM, James AW. Ang-2 but not Ang-1 expression in perivascular soft tissue tumors. J Orthop. Nov 2016; 14(1): 147-153. Corresponding author.
  13. James AW, Chiang M, Asatrian G, Shen J, Goyal R, Chung CG, Chang L, Shrestha S, Turner AS, Seim HB, Zhang X, Wu BM, Ting K, Soo C. Vertebral implantation of NELL-1 enhances bone formation in an osteoporotic sheep model. Tissue Eng Part A, Jun 2016; 22(11-12):840-9.
  14. Agarwal S, Loder S, Li S, Chan C, Mishina Y, Zhao B, James AW, Levi B. Analysis of bone-cartilage-stromal progenitor populations in trauma induced and genetic models of heterotopic ossification. Stem Cells, Jun 2016; 34(6): 1692-701.
  15. Shen J, Shrestha S, Rao NP, Asatrian G, Scott MA, Nguyen V, Giacomelli P, Soo C, Ting K, Eilber FC, Peault B, Dry SM, James AW. Pericytic mimicry in well-differentiated liposarcoma / atypical lipomatous tumor. Hum Pathol. Apr 2016, Epub ahead of print. Corresponding author.
  16. Guo M, James AW, Kwak JH, Shen J, Yokoyama KK, Ting K, Soo CB, Chiu RH. Cyclophilin A (CypA) plays dual roles in regulation of bone anabolism and resorption. Scientific Reports, Mar 2016; 6:22378.
  17. West CC, Hardy WR, Murray IR, James AW, Corselli M, Pang S, Black C, Lobo SE, Sukhija K, Liang P, Lagishetty V, Hay DC, March KL, Ting K, Soo C, Peault B. Purification of perivascular presumptive mesenchymal stem cells from human adipose tissue: process optimization and cell population metrics across a large cohort of diverse demographics. Stem Cell Res Ther, Mar 2016; 7(1): 47.
  18. Shen J, Velasco O, Khadarian K, Asatrian G, Hwang A, Zhang Y, Kwak J, Chawan C, Khalilinejad K, Ajalat M, Pritchard T, Zhang X, James AW, Soo C. A mouse femoral defect demonstrates the clinically relevant side effects of BMP-2. Int J Ortho. Nov 2015; 2(6): 468-475. Co-corresponding author.
  19. Shen J, James AW, Zhang X, Pang S, Zara JN, Asatrian G, Chiang M, Lee M, Khadarian K, Nguyen A, Lee KS, Siu RK, Tetradis S, Ting K, Soo C. Novel Wnt regulator Nell-1 antagonizes adipogenesis and augments osteogenesis induced by bone morphogenetic protein 2. Am J Path, Feb 2016; 186(2): 419-34.
  20. Chang L, Rao N, Bernthal N, Dry SM, James AW. An unusual karyotype in leiomyoma: case report and literature review. J Orthop. Nov 2015; 12(Suppl 2): S251-4. Corresponding author.
  21. Shen J, LaChaud G, Shrestha S, Asatrian G, Zhang X, Dry SM, Soo C, Ting K, James AW. NELL-1 expression in tumors of cartilage. J Orthop. Oct 2015; 12(Suppl 2): S223-9. Corresponding author.
  22. Shen J, Shrestha S, Yen YH, Scott MA, Soo C, Ting K, Dry SM, Peault B, James AW. The pericyte antigen RGS5 in perivascular soft tissue tumors. Hum Path. Jan 2016;47(1): 121-31. Corresponding author.
  23. Shen J, Shrestha S, Yen YH, Scott MA, Asatrian G, Barnhill R, Lugassy C, Soo C, Ting K, Peault B, Dry SM, James AW. Pericyte antigens in angiomyolipoma and PEComa family tumors. Med Oncol. Aug 2015; 32(8): 659. Corresponding author.
  24. Lee S, Zhang X, Shen J, James AW, Chung CG, Hardy R, Li C, Girgius C, Zhang Y, Stoker D, Wu BM, Peault B, Ting K, Soo C. hPSCs and NELL-1 synergistically enhance spinal fusion in osteoporotic rats. Stem Cells, Oct 2015; 33(10): 3158-63.
  25. Shen J, Shrestha S, Yen YH, Asatrian G, Mravic M, Soo C, Ting K, Dry SM, Peault B, James AW. Pericyte antigens in perivascular soft tissue tumors. Int J Surg Path, Dec 2015; 23(8): 638-48. Corresponding author.
  26. James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Bengs B, Culiat CT, Turner S, Seim HB, Lyons K, Adams JS, Ting K, Soo C. NELL-1 in the Treatment of Osteoporotic Bone Loss. Nature Communications, Jun 2015; 6:7362. PMCID: PMC4557288.
  27. Shen J, LaChaud G, Khadarian K, Shresthra S, Zhang X, Soo C, Ting K, Dry SM, James AW. NELL-1 expression in benign and malignant bone tumors. Biochem Biophys Res Commun, May 2015; 460(2): 368-74. Corresponding author.
  28. James AW, Chang L, Shrestha S, Tirado CA, Dry SM. An unusual complex karyotype in myopericytoma. J Orthop, Jan 2015; 12(1):58-62. PMCID: in process.
  29. Mravic M, LaChaud G, Nguyen A, Scott MA, Dry SM, James AW. Clinical and histopathological diagnosis of glomus tumor: An institutional experience of 138 cases. Int J Surg Path. Dec 2014; Accepted for publication. Corresponding author.
  30. Scott MA, Shen J, Lam K, Yen YH, Shrestha S, Mravic M, Asatrian G, Chung CG, Lugassy C, Barnhill RL, Dry SM, Peault B, James AW. Pericytes and perivascular stem cells in tumor biology. Int J Ortho. Jan 2015; 2(3): 301-306. Invited review; Corresponding author.
  31. James AW, Chang L, Genshaft S, Dry SM. Coincident liposarcoma, carcinoid and gastrointestinal stromal tumor complicating type 1 neurofibromatosis: case report and literature review. J Orthop. Nov 2014; 12(Suppl 1): S111-6.
  32. Pang S, Liu Y, Chen F, Shen J, Zheng Z, Zhang H, James AW, Hsu CY, Lee K, Wang C, Zhang X, Soo C, Ting K. Proliferation and osteogenic differentiation of mesenchymal stem cells by a short isoform of NELL-1. Stem Cells. Nov 2014; Epub ahead of print. PMCID: in process.
  33. Nguyen A, Scott MA, Dry SM, James AW. Roles of bone morphogenetic protein signaling in osteosarcoma. Int Orthop. Nov 2014; 38(11):2313-22. PMCID: in process. Corresponding author.
  34. Chung CG, James AW, Asatrian G, Liang P, Chang L, Le K, Bayani G, Pan A, Stoker D, Zhang X, Ting K, Peault B, Soo C. Human perivascular stem cell-based bone graft substitute induces rat spinal fusion. Stem Cells Transl Med. Oct 2014; 3(10):1231-41. PMCID: in process.
  35. James AW, Shen J, Khadarian K, Pang S, Nguyen A, Chang L, Asatrian G, Zhang X, Ting K, Soo C. Lentiviral encoded PPARgamma shRNA alters the balance of osteogenesis and adipogenesis, improving bone microarchitecture. Tissue Eng Part A. Oct 2014; 20(19-20):2699-710. PMCID: in process.
  36. Mravic M, Asatrian G, Soo C, Lugassy C, Barnhill RL, Dry SM, Peault B, James AW. From pericytes to perivascular tumours: correlation between pathology, stem cell biology, and tissue engineering. Int Orthop. Sep 2014; 38(9):1819-24. PMCID: in process. Corresponding author.
  37. Velasco O, James AW, Asatrian G, Ajalat M, Pritchard T, Novshadian S, Murthy A, Bayani G, Zhang X, Ting K, Soo C. High resolution X-Ray: a reliable approach for quantifying osteoporosis in a rodent model. Biores Open Access. Aug 2014; 3(4):192-6. PMCID: PMC4120930.
  38. James AW, Nguyen A, Said J, Genshaft S, Lassman CR, Teitell M. Splenic hamartomas with Alagille syndrome: Case report and literature review. Fet Pediatr Pathol. Aug 2014; 33(4):216-25. PMCID: in process.
  39. Levine BD, Seeger LL, James AW, Motamedi K. Subcutaneous panniculitis-like T-cell lymphoma: MRI features and literature review. Skeletal Radiol. Apr 2014; 43(9): 1307-11. PMCID: in process.
  40. James AW, Chang L, Levine B, Dry SM. Clavicular and meningeal alveolar soft part sarcoma: An unusual case and literature review. J Orthop. Jan 2014; 11(1):48-53. PMCID: in process.
  41. James AW, Tirado CA, Levine B, Dry SM. Abnormal karyotypes in osteochondroma: Case series and literature review. J Orthop. Jan 2014; 11(1): 48-53. PPMCID: in process.
  42. Murray IR, West CC, Hardy WR, James AW, Park TS, Nguyen A, Tawonsawatruk T, Lazzari L, Soo C, Peault B. Natural history of mesenchymal stem cells, from vessel walls to culture vessels. Cell Molecular Life Sciences. Apr 2014; 71(8):1353-74. PMCID: in process. Co-first author. Cited by 48.
  43. Deshpande S, James AW, Blough J, Donneys A, Wang SC, Cederna PS, Buchman SR, Levi B. Reconciling the effects of inflammatory cytokines on mesenchymal cell osteogenic differentiation. J Surg Res. Nov 2013; 185(1):278-85. PMCID: in process.
  44. Shen J, James AW, Zara JN, Asatrian G, Khadarian K. Zhang JB, Ho S, Kim H, Ting K, Soo C. BMP2-induced inflammation can be suppressed by the osteoinductive growth factor NELL-1. Tissue Eng Part A. Nov 2013; 19(21-22): 2390-401. PMCID: PMC3807546.
  45. Yuan W, James AW, Asatrian G, Shen J, Zara JN, Tian HJ, Siu RK, Zhang X, Wang CJ, Dong J. NELL-1 based demineralized bone graft promotes rats spine fusion as compared to commercially available BMP-2 product. J Orthop Sci. Jul 2013; 18(4):646-57. PMCID: in process. Co-first author.
  46. Askarinam A, James AW, Zara JN, Corselli M, Pan A, Chang L, Rackohn T, Stoker D, Zhang X, Ting K, Peault B, Soo C. Human Perivascular Stem Cells Show Enhanced Osteogenesis and Vasculogenesis with NELL-1 Protein. Tissue Eng Part A. Jun 2013; 19(11-12): 1386-97. PMCID: PMC3638559. Co-first author.
  47. Pan A, Chang L, Nguyen A, James AW. A review of Hedgehog signaling in cranial bone development. Front Physiol. Apr 2013; 4:61. PMCID: PMC3613593. Corresponding author.
  48. Kwak J, Zara JN, Chiang M, Ngo R, Shen J, James AW, Le KM, Moon C, Zhang X, Gou Z, Ting K, Soo C. NELL-1 injection maintains long bone quantity and quality in an ovariectomy-induced osteoporotic senile rat model. Tissue Eng Part A. Feb 2013; 19(3-4):426-36. PMCID: PMC3542871.
  49. Shen J, James AW, Chung J, Lee K, Zhang J, Ho S, Lee KS, Kim TM, Niimi T, Kuroda S, Ting K, Soo C. NELL-1 promotes cells adhesion and differentiation via IntegrinB1. J Cell Biochem. Dec 2012; 113(12): 3620-8. PMCID: in process.
  50. Chen F, Walder B, James AW, Soofer DE, Soo C, Ting K, Zhang X. Nell-1 dependent mineralization of Saos-2 human osteosarcoma cells is mediated via c-Jun N-Terminal kinase pathway activation. Int Orthop. Oct 2012; 36(10):2181-7. PMCID: PMC3460081.
  51. James AW, Zara JN, Corselli M, Askarinam A, Zhou AM, Hourfar A, Nguyen A, Megerdichian S, Asatrian G, Pang S, Stoker D, Zhang X, Wu B, Ting K, Peault B, Soo C. An abundant perivascular source of stem cells for bone tissue engineering. Stem Cells Transl Med. Sep 2012; 1(9):673-84. PMCID: PMC3659737.
  52. James AW, Pang S, Askarinam A, Chiang M, Zara JN Chang L, Yuan W, Stoker D, Zhang X, Ting K, Soo C. Additive effects of Sonic Hedgehog and Nell-1 signaling in osteogenic versus adipogenic differentiation of human adipose-derived stromal cells. Stem Cells Dev. Aug 2012; 21(12):2170-8. PMCID: PMC3411358.
  53. James AW, Zara JN, Zhang X, Askarinam A, Goyal R, Chiang M, Yuan W, Chang L, Corselli M, Shen J, Pang S, Stoker D, Ting K, Peault B, Soo C. Perivascular stem cells: a prospectively purified mesenchymal stem cell population for bone tissue engineering. Stem Cells Transl Med. Jun 2012; 1(6):510-9. PMCID: PMC3659717. Cited by 41.
  54. Cowan CM, Zhang X, James AW, TM Kim, Sun N, Soo C, Wu B, Ting K. NELL-1 increases pre-osteoblast mineralization using both phosphate transporter Pit1 and Pit2. Biochem Biophys Res Commun. May 2012; 422(3): 351-7. PMCID: in process.
  55. James AW, Zara JN, Corselli M, Chiang M, Yuan W, Nguyen V, Askarinam A, Goyal R, Siu RK, Scott V, Lee M, Ting K, Peault B, Soo C. Use of Human Perivascular Stem Cells for Bone Regeneration. J Vis Exp. May 2012; 63:e2952. PMCID: PMC3466949.
  56. Siu RK, Zara JN, Hou Y, James AW, Kwak J, Zhang X, Ting K, Wu BM, Soo C, Lee M. NELL-1 promotes cartilage regeneration in an in vivo rabbit model. Tissue Eng Part A. Feb 2012, 18(3-4):252-61. PMCID: PMC3267973.
  57. Zhang X, Ting K, Pathmanathan D, Ko T, Chen W, Feng C, Lee H, James AW, Siu R, Shen J, Culiat CT, Soo C. Calvarial cleidocraniodysplasia-like calvarial defects with ENU-induced Nell-1 deficiency. J Craniofac Surg. Jan 2012; 23(1):61-6. PMCID: PMC3282020.

Reviews

  1. James AW, Shurell E, Singh A, Dry SM, Eilber FC. Malignant peripheral nerve sheath tumor. Surg Oncol Clin N Am. Oct 2016; 25(4): 789-802.
  2. James AW, Hindle P, Murray IR, West CC, Tawonsawatruk T, Shen J, Asatrian G, Zhang X, Nguyen V, Simpson AH, Ting K, Soo C. Pericytes for the treatment of orthopedic conditions. Pharmacol Ther. Aug 2016. Epub ahead of print.
  3. Nguyen V, Nguyen A, Meyers CA, Shen J, Scott MA, James AW. The Role of Integrins in Osteosarcoma. Int J Orthop. Jun 2016; 3(3): 1-5. Invited review.
  4. Pham D, Nguyen A, Shen J, Nguyen V, Scott MA, James AW. Variation in adipose-derived stromal cells by anatomic depot. Int J Orthop. Apr 2016; 3(2): 525-527. Invited review.
  5. Chang L, Meyers CA, Asatrian G, Shen J, Scott MA, James AW. Basic and translational research in osteosarcoma: A year in review. SM Journal of Orthopaedics, Special Issue- Bone Tumors. 2016 Mar; 2(2): 1031. Invited submission.
  6. James AW, LaChaud G, Shen J, Asatrian G, Zhang X, Ting K, Soo C. A review of the clinical side effects of bone morphogenetic protein-2. Tissue Eng Part B. 2016 Feb; Epub ahead of print.
  7. Nguyen A, Pham D, Nguyen V, Chung GC, Levi B, James AW, Scott MA. Hedgehog signaling in facial and palatal development. Int J Orthop. Sep 2015; 2(5): 385-390.
  8. Chang L, Nguyen V, Nguyen A, Scott MA, James AW. Pericytes in sarcomas of bone. Med Oncol. Jul 2015; 32(7): 651. PMCID: In process.
  9. Nguyen A, Nguyen V, James AW, Scott MA. Craniomaxillofacial sources of mesenchymal stem cells: A brief review. Int J Ortho. May 2015; 2(4): 333-340.
  10. Chang L, Shrestha S, LaChaud G, Scott MA, James AW. Review of microRNA in osteosarcoma and chondrosarcoma. Med Oncol. May 2015; 32(6): 613.
  11. Chang L, Asatrian G, Dry SM, James AW. Circulating tumor cells in sarcomas: A brief review. Med Oncol. Jan 2015; 32(1):430. PMCID: in process.
  12. Nguyen A, Pham D, Nguyen V, Shen J, Scott MA, Levi B, James AW. A Brief Review of Viral Delivery Systems for Bone Tissue Engineering. Int J Ortho. Nov 2014; 1(4): 130-139. Invited review.
  13. Asatrian G, Pham D, Hardy WR, James AW, Peault B. Stem cell technology for bone regeneration: current status and potential applications. Stem Cells Cloning. Feb 2014; 8: 39-48. Invited review.
  14. Mravic M, Peault B, James AW. Current trends in bone tissue engineering. Biomed Res Int. 2014; 865270. Doi: 10.1155/2014/865270. PMCID: PMC3997160.
  15. James AW. Review of signaling pathways governing MSC osteogenic and adipogenic differentiation. Scientifica. Dec 2013; 684736. PMCID: PMC3874981. Invited Spotlight Article.
  16. Scott MA, Levi B, Askarinam, Nguyen A, Rackohn T, Ting K, Soo C, James AW. Brief review of models of ectopic bone formation. Stem Cells Dev. Mar 2012, 21(5):655-67. PMCID: PMC3295855.

Book Chapters

  1. Shen J, Nguyen V, Scott MA, Asatrian G, Shrestha S, Soo C, Ting K, Dry SM, Peault B, James AW. Pericyte antigens in mesenchymal tumors. Soft Tissue Tumors, Nov 23 2015; Invited Book Chapter.
  2. Nguyen V, Meyers CA, Nguyen A, Scott MA, James AW. Epigenetic regulation in osteosarcoma. Horizons in Cancer Research. NOVA Publishers. Sep 2015; In Press. Invited Book Chapter.
  3. Santamaria A, Asatrian G, Chen WCW, James AW, Hardy W, Caplan A, Soo C, Peault B. Ch. 15 Nature or nurture: Mesenchymal stem cells for tissue regeneration. Advances in Translational Medicine. Part IV: Cell Therapies and Other Applications. Invited Book Chapter.
  4. James AW, Dry SM. Diagnostically challenging epithelioid soft tissue tumors. Surgical Pathology Clinics: Soft Tissue Pathology. 2015 Sep; 8(3): 309-29. Invited Review.
  5. Mravic M, Nguyen A, Scott MA, James AW. Emerging signaling pathways for future therapies in Osteosarcoma: Wnt, Notch and Hedgehog signaling. Osteosarcoma: Symptoms, Diagnosis, and Treatment Options. NOVA Publishers. Dec 2013; In press. Invited Book Chapter.
  6. Asatrian G, Pan A, Scott MA, James AW. Chapter 1, Safety assessments in mesenchymal stem cell implantation. Frontiers in Stem Cell and Regenerative Medicine Research. Jun 2014; Epub ahead of print. Invited Book Chapter.
  7. Nguyen A, Chang L, Scott MA, James AW. Chapter 1, Molecular determination of adipogenic versus osteogenic differentiation in mesenchymal stem cells. Adipogenesis: Signaling Pathways, Molecular Regulation and Impact on Human Disease. NOVA Biomedical, New York. Eds: Y Lin and X Cai. Jul 2013. Invited Book Chapter.
  8. Asatrian G, Chang L, James AW. Muscle pouch implantation: an ectopic bone formation model. Methods Mol Biol. 2014; 1213:185-91. PMCID: in process.