February 2011

In collaboration with the laboratory of Nick Gaiano, our group has published a study showing that Notch3 can efficiently induce glioma formation in the optic nerve and retina, but not in the brain. Other ocular tumors and abnormalities were also noted. This work suggests that glial precursors in the eye and optic nerve may be intrinsically different from those in the brain. The paper “Notch3 activation promotes invasive glioma formation in a tissue site-specific manner” was published in Cancer Research, and Tarran Pierfelice was the first author.

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