We are so excited and honored to be awarded one of the 2016 Prostate Cancer Foundation Challenge Awards to study the microbiome in relation to metastatic prostate cancer!
We are so excited and honored to be awarded one of the 2016 Prostate Cancer Foundation Challenge Awards to study the microbiome in relation to metastatic prostate cancer!
Sfanos and De Marzo labs, December 2016
L to R: Michele Fountain, Dr. William Nelson, Nicki Castagna, Stephanie Papadopoulos
Sfanos lab members read ” ‘Twas the night after grant submission “
It has been an amazing year! Looking forward to many discoveries in 2017!
We recently published an article in The Prostate on a multi-disciplinary study led by Pathobiology graduate student Heidi Hempel. Heidi has been taking a close look at mast cells (inflammatory cells that are known for their prototypical role in allergic responses) in relation to prostate cancer aggressiveness. Somewhat surprisingly, she discovered that low numbers of mast cells in a prostate tumor confer a higher risk of biochemical recurrence after radical prostatectomy. The link to the new study can be found here:
http://onlinelibrary.wiley.com/doi/10.1002/pros.23280/full
Sfanos lab members, family, and friends will be participating in the Prevent Cancer Foundation’s annual 5K fundraising event on Sept. 25th at Nationals Park. “Team Prostate” has been participating in the event since 2011. Visit https://www.preventcancer5k.org/teamprostate to learn more and to support the team!
What an awesome experience to meet prostate cancer survivor Gary Newell and participate in the annual video for the V Foundation. September is prostate cancer awareness month – it’s a great time to donate to amazing organizations like the V Foundation who fund early career investigators who are passionate about finding a cure!
See the video here: http://jimmyv.convio.net/site/MessageViewer?em_id=8743.0&dlv_id=20042
Left to right: Dr. Michael Haffner, Dr. Angelo De Marzo, Dr. Javier Baena-Del Valle, Heidi Hempel, Corey Porter
Nature recently published a great Outlook Supplement on prostate cancer including an article that highlights our team at Johns Hopkins. See the article here: Microbiology: Inflammatory evidence. The article features ongoing work by Dr. Angelo De Marzo, Dr. William Nelson, Dr. Elizabeth Platz, Dr. Scott Lucia, and others on a potential role for chronic inflammation in prostate carcinogenesis. For more information on this topic, see Nelson et al NEJM, 2003 and De Marzo et al Nature Rev. Cancer, 2007.
http://www.nature.com/nature/journal/v528/n7582_supp/full/528S130a.html
Dr. Sfanos received a 2014 V Scholar Award from The V Foundation for Cancer Research to study alterations in the urinary tract microbiome as a risk factor for prostate cancer. Stay tuned for exciting research updates from this project! To learn more about the V Foundation for Cancer Research go to http://www.jimmyv.org/. Also, stay tuned for ESPN’s annual V Week coming up in December and please consider making a donation to this awesome organization!
IL-6 mRNA-expressing cells (brown staining) are highly enriched in the stroma in areas of acute inflammation in the prostate.
New from the Sfanos lab! A Paracrine Role for IL6 in Prostate Cancer Patients: Lack of Production by Primary or Metastatic Tumor Cells. Punchline: Prostate cancer cells don’t express IL6, but the microenvironment does!