Select Peer-Reviewed Publications
Sfanos K.S., Sauvageot J., Fedor H.L., Dick J.D., De Marzo A.M., Isaacs W.B. A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microorganisms. Prostate, 68(3):306-320, 2008.
Sfanos K.S., Bruno T.C., Maris C.H., Xu L., Thoburn C.J., De Marzo A.M., Meeker A.K., Isaacs W.B., Drake C.G. Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clinical Cancer Research, 14:3254-3261, 2008.
Sfanos K.S., Wilson B.A., De Marzo A.M., Isaacs W.B. Acute inflammatory proteins constitute the organic matrix of prostatic corpora amylacea and calculi in men with prostate cancer. Proceedings of the National Academy of Sciences (PNAS) U.S.A., 106:3443-3448, 2009.
Sfanos K.S., Bruno T.C., Meeker A.K., De Marzo A.M., Isaacs W.B., Drake C.G. Human prostate-infiltrating CD8+ T lymphocytes are oligoclonal and PD-1+. Prostate, 69(15):1694-1703, 2009.
Aloia A.L., Sfanos K.S.*, Isaacs W.B., Zheng Q., Maldarelli F., De Marzo A.M., Rein A. XMRV: A new virus in prostate cancer? Cancer Research, 70:10028-10033, 2010.
Sfanos, K.S., Aloia, A.L., Hicks, J.L., Esopi, D.M., Steranka, J.P., Shao, W., Sanchez-Martinez, S., Yegnasubramanian, S., Burns, K.H., Rein, A., De Marzo, A.M. Identification of replication competent murine gammaretroviruses in commonly used prostate cancer cell lines. PLoS ONE, 6(6): e20874, 2011.
Sfanos, K.S., De Marzo, A.M. Prostate cancer and inflammation: The evidence. Histopathology, 60(1):199-215, 2012.
Sfanos, K.S., Aloia, A.L., De Marzo, A.M., Rein, A. XMRV and prostate cancer: A “final” perspective. Nature Reviews Urology, 9:111-118, 2012.
Mak, T.N., Fischer, N., Laube, B., Brinkmann, V., Metruccio, M.M.E., Sfanos, K.S., Mollenkopf, H.-J., Meyer, T.F., Bruggemann, H. Propionibacterium acnes host cell tropism contributes to vimentin-mediated invasion 1 and induction of inflammation. Cellular Microbiology, 14(11):1720-1733, 2012.
Mak, T.N., Yu, S.H., De Marzo, A.M.,  Brüggemann, H., Sfanos, K.S. Multilocus Sequence Typing (MLST) analysis of Propionibacterium acnes isolates from radical prostatectomy specimens.  Prostate, 73(7):770-777, 2013.
Shinohara, D.B., Vaghasia, A., Yu, S.H., Mak, T.N., Brüggemann, H., Nelson, W.G., De Marzo, A.M., Yegnasubramanian, S., Sfanos, K.S. A mouse model of chronic prostatic inflammation using a humal prostate cancer-derived isolate of Propionibacterium acnes. Prostate, 73(9):1007-1015, 2013.
Fischer, N., Mak, T.N., Shinohara, D.B., Sfanos, K.S., Meyer, T.F., Brüggemann, H. Deciphering the intracellular fate of Propionibacterium acnes in macrophages. BioMed Research International, 2013, Article ID 603046, 2013.
Hempel, H.A., Burns, K.H., De Marzo, A.M., Sfanos K.S. Infection of xenotransplanted human cell lines by murine retroviruses: A lesson brought back to light by XMRV. Frontiers in Oncology,3:156, 2013. doi: 10.3389/fonc.2013.00156.
Mak, T.N., Schmid, M., Brzuszkiewicz, E., Zeng, G., Meyer, R., Sfanos, K.S., Brinkmann, V., Meyer, T.F., Brüggemann, H. Comparative genomic insight into human-associated propionibacteria reveals distinct host-interacting traits of P. acnes, P. granulosum and P. avidum. BMC Genomics, 14:640, 2013.
Canene-Adams, K., Sfanos, K.S., Liang, D., Yegnasubramanian, S., Nelson, W.G., Brayton, C., De Marzo, A.M. Dietary chemoprevention of PhIP induced carcinogenesis in male Fischer 344 rats with tomato and broccoli. PLOSone, 8(11): e79842, 2013.
Sfanos, K.S., Isaacs, W.B., De Marzo, A.M. Infections and inflammation in prostate cancer. American Journal of Clinical and Experimental Urology, 1(1):3-11, 2013.
Darshan, M., Zheng,Q., Fedor,H.L., Wyhs, N., Yegnasubramanian, S., Lee, P., Melamed, J., Netto, G.J., Trock, B.J., De Marzo, A.M., Sfanos, K.S. Biobanking of derivatives from radical retropubic and robot-assisted laparoscopic prostatectomy tissues as part of the prostate cancer biorepository network. Prostate, 74(1): 61-69, 2014.
Liang, J., Li, Y., Daniels, G., Sfanos, K., De Marzo, A., Wei, J., Li, X., Cheng, W., Wang, J., Zhong, X., Melamed, J., Zhao, J., Lee, P. LEF1 targeting EMT in prostate cancer invasion is regulated by miR-34a. Molecular Cancer Research, 13(4):681-8, 2015.
Sfanos, K.S., Canene-Adams, K., Hempel, H., Yu, S.H., Simons, B., Schaeffer, A., Schaeffer, E., Nelson, W.G., De Marzo, A.M. Bacterial prostatitis enhances 2-amino-1-methyl-6-phenylimidazo [4, 5-β] pyridine (PhIP)-induced cancer at multiple sites. Cancer Prevention Research, 2015 doi:.
Yu, S.H., Zheng, Q., Esopi, D., Macgregor-Das, A., Luo, J., Antonarakis, E.S., Drake, C.G., Vessella, R., Morrissey, C., De Marzo, A.M., Sfanos, K.S. A paracrine role for IL-6 in prostate cancer patients: Lack of production by primary or metastatic tumor cells. Cancer Immunology Research, 2015 doi:.
Hempel H.A., Cuka N.S., Kulac I., Barber J.R., Cornish T.C., Platz E.A., De Marzo A.M., Sfanos K.S. Low intratumoral mast cells are associated with a higher risk of prostate cancer recurrence. Prostate, 2017 DOI:10.1002/pros.23280.
Huang F.W., Mosquera J.M., Garofalo A., Oh C., Baco M., Amin-Mansour A., Rabasha B., Bahl S., Mullane S.A., Robinson B.D., Aldubayan S., Khani F., Karir B., Kim E., Chimene-Weiss J., Hofree M., Romanel A., Osborne J.R., Kim J.W., Azabdaftari G., Woloszynska-Read A., Sfanos K., De Marzo A.M., Demichelis F., Gabriel S., Van Allen E.M., Mesirov J., Tamayo P., Rubin M.A., Powell I.J., Garraway L.A. Exome sequencing of African-American prostate cancer reveals loss-of-function ERF mutations. Cancer Discovery, 2017 DOI: 10.1158/2159-8290.CD-16-0960.
Shrestha E., White, J.R., Yu, S.H., Kulac, I., Ertunc, O., De Marzo, A.M., Yegnasubramanian, S., Mangold, L.A., Partin, A.W., Sfanos, K.S. Profiling the urinary microbiome in men with positive versus negative biopsies for prostate cancer. Journal of Urology, 2018 DOI:
Sfanos, K.S., Yegnasubramanian, S., Nelson, W.G., De Marzo, A.M. The inflammatory microenvironment and microbiome in prostate cancer development. Nature Reviews Urology, 2018 DOI:10.1038/nrurol.2017.167.
Porter C.M., Shrestha E., Peiffer L.B., Sfanos K.S. The microbiome in prostate inflammation and prostate cancer. Prostate Cancer and Prostatic Diseases, 2018; 21:345-354.
Sfanos K.S., Markowski M.C., Peiffer L.B., Ernst S.E., White J.R., Pienta K.J., Antonarakis E.S., Ross A.E. Compositional differences in gastrointestinal microbiota in prostate cancer patients treated with androgen axis-targeted therapies. Prostate Cancer and Prostatic Diseases, 2018; 21:529-548.
Yu S.H., Maynard J.P., Vaghasia A.M., De Marzo A.M., Drake C.G., Sfanos K.S. A role for paracrine interleukin-6 signaling in the tumor microenvironment in prostate tumor growth. Prostate, 2019; 79(2):215-222.
Markowski MC, Boorjian SA, Burton JP, Hahn NM, Ingersoll MA, Maleki Vareki S, Pal SK, Sfanos KS. The microbiome and genitourinary cancer: A collaborative review. European Urology. 2019;75(4):637-646.
Complete list of publications.