Our Team

Principal Investigator

Vassilis E. Koliatsos, MD MBA

e-mail: koliat@jhmi.edu

Dr. Koliatsos, Professor of Pathology and Neurology and Associate Professor of Psychiatry and Behavioral Sciences, is the head of the Laboratory. Dr. Koliatsos trained in systems neuroscience with Mahlon DeLong and cellular and molecular neuropathology with Don Price. His main interest is mechanisms of neural injury and repair relevant to human disease. He has previously characterized a number of neurotrophic factors for key populations of neurons in the brain and spinal cord and initiated experimental therapies of spinal cord diseases with stem cells and their progenies. In recent years, Dr. Koliatsos has turned to the problem of traumatic brain injury, both as morbidity in and of itself and as model for neurodegenerative disorders. He serves on the faculty of the Ph.D. graduate program of Pathobiology of Disease and leads the TBI Research Center in the Department of Pathology. A clinical neuropsychiatrist, he also sees patients with TBI and degenerative dementias. Dr. Koliatsos has received a Leadership and Excellence in Alzheimer’s disease Award and the Javits Neuroscience Investigator Award from NIH and a 2018 Discovery Award from Johns Hopkins University.

Lab Manager/Assistant

Jiwon Ryu, PhD

e-mail: jryu4@jhmi.edu

Dr. Ryu, with PhD background in Microbiology/Immunology, is the laboratory manager and leads efforts in molecular biology and protein work. She is broadly trained in a wide variety of methodologies, with emphasis on the manipulation and differentiation of ES and IPS cells. Her current research emphasis is in vitro assays of genetic and pharmacological tools to protect human and rodent axons from Wallerian-type degeneration.

Post-Doctoral Research Fellows

Nikolaos Ziogas, MD

e-mail: nziogas1@jhmi.edu

Dr. Ziogas, senior postdoctoral research fellow and a Johns Hopkins University School of Medicine – Libra Awardee, models diffuse axonal injury in brain stem and visual circuitries using CLARITY enhanced with advanced microscopy, transgenic methodologies, and neurochemistry. He is presently working on molecular pathways responsible for Wallerian degeneration with emphasis on SARM1 signaling and explores ways to target these pathways in order to protect axons and develop experimental therapies for traumatic axonopathy. He also wants to import lessons from traumatic axonopathies into mechanisms of degenerative tauopathies, especially Alzheimer’s disease.

Thanasis Alexandris, MD

e-mail: aalexa27@jhmi.edu

Dr. Alexandris, postdoctoral research fellow with background in Neuropathology, explores ways to block the mixed lineage (DLK/LZK) cascade along with SARM1 signaling in models of traumatic axonal injury in vitro and in vivo. Well published in the field of neurodegenerative disease/Lewy body dementias, he is also interested in exploring parallels between traumatic axonopathy and axonal and other pathology in human synucleopathies.

Research Specialist

Nicholas Stewart, BS

Nick Stewart is a research specialist with expertise in electron microscopy and other neuroanatomical methods. He spends most of his time helping with visualization of injured axons, axonal ultrastructure, and quantitation of traumatic axonopathy with and without treatment.

Undergraduate Students

Miles Gilliam

Mr. Gilliam, senior at Hopkins with major in Neuroscience, is working to characterize the functional/behavioral consequences of TBI in motor pathways and the effects of genetic and pharmacological interventions targeting SARM1. He is a four-year starter for the Hopkins wrestling team and plans to attend medical school in the future.

Matt Harris

Mr. Harris, also a Neuroscience senior at Hopkins, is working on the quantitation of axonal survival after TBI in select CNS tracts with various genetic and pharmacological interventions.