Principal Investigator

Chuan-Hsiang (Bear) Huang, M.D., Ph.D.

Bear received an M.D. from National Taiwan University and Ph.D. from the Johns Hopkins University. His Ph.D. work focused on structural studies of PI3Kα, one of the most frequently mutated proteins in human cancers and an important drug target. Using X-ray diffraction methods, Bear determined the first crystal structure of the PI3Kα heterodimer, elucidating the basis of PI3K over-activation in cancers. To further understand the cellular biology of PI3K signaling, Bear conducted his postdoctoral research in the Devreotes lab, studying the mechanism of cell migration and chemotaxis using Dictyostelium and human neutrophils as models. Bear combined single cell imaging with quantitative modeling to reveal the dynamic properties of the Ras-PI3K signaling network, how it couples to the cytoskeleton, and how chemotactic cues bias this coupling to guide movement. In 2016 Bear started his own lab in the Department of Pathology at Johns Hopkins where his team investigates the fundamental mechanisms of cell motility as well as implications in human diseases such as metastatic cancers.

Postdoctoral Fellow

Jr-Ming Yang, Ph.D.

• B.S., National Taiwan University (Taiwan)
• M.S., National Taiwan University (Taiwan)
• Ph.D., Johns Hopkins University School of Medicine (U.S.)

Graduate Students

Huiwang (David) Zhan (co-mentored)

  • Ph.D. student
  • Graduate Program: Biological Chemistry

Budri Abubaker-Sharif (co-mentored)

  • M.D./Ph.D. student
  • Graduate Program: Biomedical Engineering

Research Technician

Chen-Yu (Jennifer) Chang, M.S.

• B.S., University of San Francisco (U.S.)
• M.S., National Yang-Ming University (Taiwan)