The Cihakova lab at the Division of Immunology, Department of Pathology, Johns Hopkins University is seeking a postdoctoral fellow to research inflammatory heart disease, cardiac fibrosis and remodeling. The research is supported by NIH RO1. We employ murine models of inflammatory heart disease, experimental autoimmune myocarditis (EAM) and Myocardial Infarction (MI) to investigate factors that modulate development of heart failure. Our laboratory is one of the leaders in the cardiac inflammation – Baldeviano et al, Circ Research 2011 and Wu L, JEM 2014. We are very productive laboratory, with several papers published yearly in high impact journals. Cihakova lab students and fellows often receive grants and awards for their work. The Cihakova lab students and fellows work in a friendly environment of collaboration and help each other to achieve the best results with a full support of the PI. A successful candidate for this open position will investigate factors that modulate development of cardiac inflammation. We were the first to show that cardiac fibroblast produce significant amount of GM-CSF and other cytokines/chemokines and that it drives cardiac remodeling and heart failure. The candidate will continue in this area of research. She/he will perform in vivo and ex vivo mouse experiments including MI and EAM induction and a variety of other general laboratory experiments such as multicolor flow cytometry skills, RT-PCR, PCR, ELISA, in vitro cultures etc. Salary and benefits will be calculated according to with NIH post-doctoral pay scales.
The new fellow should be highly motivated, dedicated, with attention to details, with a proven track record of productivity. The candidate should be able to create new hypothesis, prepare experimental protocols, execute the experiments and prepare rigorous data analysis with help of the PI. Good writing/oral skills in English are expected. The desired candidate will have immunology training, research experience in mouse models is a plus, excellent multicolor flow cytometry skills, RT-PCR, PCR, ELISA, training in in vitro cultures. Experience in Myocardial Infarction mouse models is a plus; however the candidate will be offered training in the model (as well as in EAM model). Candidate should possess a Ph.D. in Biomedical Sciences or a related field, with no more than 3 years of postdoctoral experience and successful track record of first author publications and good references.
Daniela Cihakova, MD, PhD, D(ABMLI)
Johns Hopkins University