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Interleukin-10 stiffens the heart

Daniela Čiháková



Cardiac Autoimmunity: Myocarditis.

Bracamonte-Baran W, Čiháková D.

Adv Exp Med Biol2017;1003:187-221. doi: 10.1007/978-3-319-57613-8_10. Review.

Čiháková DEaton WWTalor MVHarkus UHDemyanovich HKRodriguez KFeldman SKelly DL.

 2017 Sep 5. pii: S0920-9964(17)30527-3. doi: 10.1016/j.schres.2017.08.051. [Epub ahead of print

PMID: 28886891 DOI: 10.1016/j.schres.2017.08.051 


Regulation of autoimmune myocarditis by host responses to the microbiome.

Barin JG, Talor MV, Diny NL, Ong S, Schaub JA, Gebremariam E, Bedja D, Chen G, Choi HS, Hou X, Wu L, Cardamone AB, Peterson DA, Rose NR, Čiháková D.

Exp Mol Pathol. 2017 Aug 16. pii: S0014-4800(17)30415-X. doi: 10.1016/j.yexmp.2017.08.003. [Epub ahead of print]



 Eosinophils in autoimmune diseases
Diny NL, Rose NR, Čiháková D.

Front Immunol. 2017 Apr 27;8:484. doi: 10.3389/fimmu.2017.00484. eCollection 2017. Review.

Jillian A. Fontes,Jobert G. Barin,Monica V. Talor,Natalie Stickel,Julie Schaub,Noel R. Rose,Daniela Čiháková

Immunity, Inflammation and Disease 13 March 2017


Eosinophil-derived IL-4 drives progression of myocarditis to inflammatory dilated cardiomyopathy.

Diny NL1, Baldeviano GC2, Talor MV2, Barin JG2, Ong S1, Bedja D3, Hays AG3, Gilotra NA3, Coppens I1, Rose NR1,2, Čiháková D4,2.

J Exp Med. 2017 Mar 16. pii: jem.20161702. doi: 10.1084/jem.20161702. [Epub ahead of print]

PMID: 28302646


Natural killer cells in inflammatory heart

SuFey Onga, 1,Noel R Rosea, b, 2,Daniela Cihakovaa, b

Clinical Immunology 2016 Nov 2016. http://dx.doi.org/10.1016/j.clim.2016.11.010

Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart.

Diny NL, Hou X, Barin JG, Chen G, Talor MV, Schaub J, Russell SD, Klingel K, Rose NR, Čiháková D.

Eur J Immunol. 2016 Sep 12. doi: 10.1002/eji.201646557. [Epub ahead of print] PMID:27621211


Collaborative Interferon-γ and Interleukin-17 Signaling Protects the Oral Mucosa from Staphylococcus aureus.

Barin JG1, Talor MV1, Schaub JA1, Diny NL2, Hou X2, Hoyer M1, Archer NK3, Gebremariam ES1, Davis MF4, Miller LS3, Rose NR5, Čiháková D6.

Am J Pathol. 2016 Jul 25. pii: S0002-9440(16)30220-6. doi: 10.1016/j.ajpath.2016.07.001. [Epub ahead of print]



Pathogenic IL-23 signaling is required to initiate GM-CSF-driven autoimmune myocarditis in mice.

Wu L, Diny NL, Ong S, Barin JG, Hou X, Rose NR, Talor MV, Čiháková D*. Eur J Immunol. 2016 Mar;46(3):582-92. doi: 10.1002/eji.201545924. Epub 2016 Jan 12.

Featured in publishing journal’s “In this issue”: IL-23 starts the avalanche and ensures destruction


Natural killer cells limit cardiac inflammation and fibrosis by halting eosinophil infiltration.

Ong S, Ligons DL, Barin JG, Wu L, Talor MV, Diny N, Fontes JA, Gebremariam E, Kass DA, Rose NR, Čiháková D*. Am J Pathol. 2015 Mar;185(3):847-61. doi: 10.1016/j.ajpath.2014.11.023. Epub 2015 Jan 23.


Cardiac fibroblasts mediate IL-17A-driven inflammatory dilated cardiomyopathy.

Wu L, Ong S, Talor MV, Barin JG, Baldeviano GC, Kass DA, Bedja D, Zhang H, Sheikh A, Margolick JB, Iwakura Y, Rose NR, Ciháková D* J Exp Med. 2014 Jun 30;211(7):1449-64. doi: 10.1084/jem.20132126. Epub 2014 Jun 16.


Faculty of 1000 Review

Picture featured in sidebar of Table of Contents: J Exp Med June 2014 Table of Contents


The varying faces of IL-6: From cardiac protection to cardiac failure.

Fontes JA, Rose NR, Čiháková D*Cytokine. 2015 Jul;74(1):62-8. doi: 10.1016/j.cyto.2014.12.024. Epub 2015 Jan 31.


Fatal eosinophilic myocarditis develops in the absence of IFN-γ and IL-17A.

Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Fairweather D, Bedja D, Stickel NR, Fontes JA, Cardamone AB, Zheng D, Gabrielson KL, Rose NR, Ciháková D*. J Immunol. 2013 Oct 15;191(8):4038-47. doi: 10.4049/jimmunol.1301282. Epub 2013 Sep 18.


Control of inflammatory heart disease by CD4+ T cells.

Barin JG, Čiháková D*. Ann N Y Acad Sci. 2013 May;1285:80-96. doi: 10.1111/nyas.12134.


Susceptibility to autoimmune myocarditis is associated with intrinsic differences in CD4(+) T cells.

Chen P, Baldeviano GC, Ligons DL, Talor MV, Barin JG, Rose NR, Ciháková D*. Clin Exp Immunol. 2012 Aug;169(2):79-88. doi: 10.1111/j.1365-2249.2012.04598.x.


Macrophage diversity in cardiac inflammation: a review.

Barin JG, Rose NR, Ciháková D*. Immunobiology. 2012 May;217(5):468-75. doi: 10.1016/j.imbio.2011.06.009. Epub 2011 Jun 30.


Macrophages participate in IL-17-mediated inflammation.

Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Quader F, Chen P, Zheng D, Caturegli P, Rose NR, Ciháková D*. Eur J Immunol. 2012 Mar;42(3):726-36. doi: 10.1002/eji.201141737. Epub 2012 Jan 23.


Mechanisms of IFNγ regulation of autoimmune myocarditis.

Barin JG, Talor MV, Baldeviano GC, Kimura M, Rose NR, Ciháková D*. Exp Mol Pathol. 2010 Oct;89(2):83-91. doi: 10.1016/j.yexmp.2010.06.005. Epub 2010 Jun 25.


Interleukin-17A is dispensable for myocarditis but essential for the progression to dilated cardiomyopathy.

Baldeviano GC, Barin JG, Talor MV, Srinivasan S, Bedja D, Zheng D, Gabrielson K, Iwakura Y, Rose NR, Čiháková D*. Circ Res. 2010 May 28;106(10):1646-55. doi: 10.1161/CIRCRESAHA.109.213157. Epub 2010 Apr 8.

Featured in publishing journal’s “In this issue”: IL-17A Is Essential for Dilated Cardiomyopathy





*Corresponding author



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